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Therefore, the Nrf2 pathway is essential to prevent diseases with oxidative stress and inflammation as basic pathologic characters

Kalamkar S, Acharya J, Kolappurath Moothan N, et al

Interestingly, in the cytoplasm of infected cells in ineffective mutants, especially the sym33-3 mutant, the amount of GSH label was increased compared with that in the wild type (Table 2)

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In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau